There are a number of different reasons why joint pain occurs including arthritis, sports injury, and the aging process. The levels of glucosamine in your cartilage naturally decrease as you get older. This cartilage is the tissue that cushions the joints.
Glucosamine is produced within the body around the joints, helping to build your cartilage and protecting it. It can help slow the process of decreased flexibility and the breakdown of cartilage and collagen. In addition to pain, glucosamine sulfate has also been taken for; weight loss, osteoarthritis, glaucoma, IBS, multiple sclerosis, and interstitial cystitis. Chondroitin is similar to glucosamine and can also be found naturally in human joints. Chondroitin prevents inflammatory enzymes from going into the synovial fluid, which helps prevent damage to your cartilage.
Glucosamine sulfate is effective for relieving joint pain. Consumers have relied on it for many years for its pain relief properties. Finding the best glucosamine supplement also helps. Glucosamine and chondroitin are often found together in supplements because it is believed that they work as a duo to support joint cartilage.
It’s not advisable to take glucosamine chondroitin supplement if you have diabetes or are taking a blood thinner. If you’re dealing with diabetes, you need to consult with your doctor before supplementing with glucosamine sulfate. This is the main active ingredient in the following products:
Vimerson Glucosamine Chondroitin with Turmeric and MSM

It contains turmeric and MSM, specific compounds added to the formula to assist with pain relief and improved range of motion. Glucosamine Chondroitin with Turmeric and MSM assists your body with repairing cartilage.
The product was created to improve the mobility of your joints. The product has a number of admirable features such as; improving the flexibility and structure of joints, lowering inflammation, and assistance with digestion.
Weight and age can play a part in joint pain and this product helps to alleviate that discomfort. It’s specifically designed for those experiencing joint pain or stiffness.
Helps with the restoration of joint collagen. The formula contains 1500mg of Glucosamine Sulfate and 150mg of Chondroitin Sulfate. It also has 150mg of Turmeric and 25mg of MSM. Other ingredients include Bromelain, which assists with digestion, Methionine, Boswellia Extract, and Quercetin.
Quercetin helps to alleviate joint pain by attacking the synovial membrane in the joints-this membrane otherwise leads to pain. It also helps prevent your body from losing cartilage. Quercetin should be taken by those who want to help prevent bone loss and weakness.
Bromelain is made up of enzymes. These enzymes help reduce infection associated with inflammation caused by an injury. Boswellia extract is also called Indian frankincense. It’s an anti-inflammatory resin from the Boswellia tree that helps reduce the symptoms of rheumatoid arthritis and osteoarthritis among other conditions.
Chondroitin works as a lubricant for the joints which helps prevent their breakdown. The slipperiness of Chondroitin helps prevent bones from pushing on each other and causing excess friction.
This supplement is primarily taken to assist with inflammatory response and pain relief in the hands, knees, and back. According to Vimerson Health, the Glucosamine Chondroitin in this product is derived from shellfish or crustaceans. None of the ingredients are synthetic and were naturally sourced from the earth.
A 2009 study found that turmeric had pain-relieving qualities just as powerful as ibuprofen. Turmeric is better absorbed by fat, so it’s a good idea to take this supplement with food.
Top features:
- Turmeric has powerful pain relief qualities and lowers inflammation
- Boswellia extract reduces rheumatoid arthritis symptoms
- Quercetin helps reduce bone loss and joint pain
- MSM with antioxidants that help repair joint cartilage
Doctor’s Best Glucosamine Chondroitin with MSM

Are you experiencing joint pain or inflammation? This may be a product you’ll want to try. The formula was designed for people in pain from muscle overuse, osteoarthritis, and general wear and tear. The product contains specially formulated OptiMSM, a 99.9% pure form of MSM. The methods used to source the MSM far exceed the standards set forth by the United States Pharmacopeia.
Doctor’s Best Glucosamine Chondroitin with MSM is not necessarily meant to relieve pain induced by sports incidents. The makers of the product recommend taking this to help with pain from osteoarthritis. This product has been found to be more effective for osteoarthritis than taking glucosamine sulfate or chondroitin with glucosamine HCL alone. This product helps with both long term and short term muscle pain.
The glucosamine in this Doctor’s Best product assists your body with building healthy joints. Three ingredients in this particular product help the body produce proteoglycans that support healthy joints. The presence of proteoglycans supports your body’s joint structure. This product also carries the benefit of supporting healthy skin, hair, and nails.
The product contains 1500mg of glucosamine sulfate, 1000mg of MSM, 180mg of potassium, and 1200mg of Chondroitin sulfate. Out of all of the products, this one contains the greatest amount of MSM. The MSM is a rich source of antioxidants and also assists with building healthy joints. It also contains the most Chondroitin.
Chondroitin helps your joints absorb shock and remain elastic. The formula is free of GMOs, soy, and gluten. The makers of this product derive glucosamine from crab and shrimp shells.
Doctor’s Best Glucosamine Chondroitin with MSM scores high in nutritional value, purity, and the use of safe ingredients. One serving is four capsules and there are 60 servings in each container. The capsules can be taken with or without food.
Top features:
- Helps alleviate pain from osteoarthritis
- Natural ingredients that support skin, hair, and nail growth
- 99.9% pure MSM
- Chondroitin attracts water and helps joint elasticity
Move Free Advanced Plus MSM with Glucosamine & Chondroitin

If you have creaky or loud knees, you might find great relief in this product. The formula contains Uniflex, a special formula that helps protect cartilage and joint tissue. Uniflex goes by another name as well, FruiteX-B Calcium Fructoborate.
It’s a mineral complex that works in two weeks to support joint comfort. Hyaluronic acid was added to the formula to help cushion the joints. Hyaluronic acid decreases as you get older and it’s needed to help you move smoothly and lubricate your joints.
Move Free Advanced Plus contains 1500mg of glucosamine hydrochloride, 1500mg of MSM, 216mg of Uniflex, 200mg of Chondroitin sulfate, and 3.3mg of hyaluronic acid. The product has joint fluid listed in the formula which is simply hyaluronic acid. The crustaceans used to source glucosamine include crab, crayfish, lobster, and shrimp.
One serving is three tablets and each serving should be taken with a meal. Move Free Advanced Plus supports comfort, mobility, strength, and flexibility. Glucosamine hydrochloride is more concentrated than glucosamine sulfate. The hydrochloride form also contains less sodium.
When taken orally, hyaluronic acid is directly absorbed by the joints. Your body naturally produces hyaluronic acid (HA), so it’s ready to absorb it and put it to use. This product has been found to effectively reduce sore joints. Consumers of this product have stated that it takes approximately 3-4 weeks to feel the effects of taking it. It’s been highly rated by a consumer who has had shoulder surgery resulting in the removal of some cartilage.
Move Free Advanced Plus MSM is also used by those who have taken glucosamine supplements for years and want to continue. Consumers also report reduced joint pain in the knees, stiffness, and popping. A retiree who underwent spine operations stated that this product assisted with her mobility.
- It contains Uniflex to help protect cartilage and joint tissue.
- It contains lubricating hyaluronic acid to relieve joint pain.
- Reduces how quickly cartilage breaks down and stimulates its growth.
- Reduces osteoarthritis pain
Nature Made TripleFlex Triple Strength Caplets

Nature Made TripleFlex Triple Strength Caplets support the formation of joint cartilage and collagen within the body by providing it with MSM. The serving size is two caplets per day and it’s designed to be taken with food and water. Some people find that the product works so well that they only take half of the regular dosage.
The capsules contain 1500mg of glucosamine hydrochloride, 800mg of chondroitin sulfate, and 750mg of MSM. Chondroitin enhances the shock-absorbing effects in your joint cartilage. It also blocks the enzymes which break down your joint cartilage. This preventative effect makes this a good supplement for someone looking to prevent cartilage damage.
TripleFlex doesn’t contain artificial dyes, flavoring, or preservatives. Consumers have reported relief in their ankles, hips, and knees after taking the product. It’s also been reported that joint soreness and stiffness have disappeared. The product is also good for soreness caused by exercise. This product is a good choice for those involved in heavy workouts that are prone to injury or strain.
It has also helped alleviate neck stiffness and enhanced range of motion. Many people take this product to alleviate joint pain caused by arthritis. It takes approximately 4-6 weeks on average to feel the effects of taking Nature Made TripleFlex. After some time, you may experience enhanced mobility in your knees and elbows.
Many consumers are impressed with the pain-relieving effect of Nature Made TripleFlex. Consider taking this product if you’re dealing with leg cramps, hand strength, leg aches, and general stiffness. Relieve arthritis in your hands and return to golf. Many people report a variety of physical improvements
after taking this product. There are a number of consumers who have used this product for years and continue to re-buy it
Top features:
- A good choice for pain relief caused by heavy exercise or workouts
- A powerful combination of glucosamine hydrochloride, MSM, and Chondroitin sulfate
- Potent with chondroitin to help prevent the breakdown of cartilage
- Alleviates stiffness and soreness
Puritan’s Pride Glucosamine Sulfate

Unlike the rest of the products reviewed here, this product by Puritan’s Pride contains one simple ingredient. There is no chondroitin present in this product. The formula consists of 1000mg of glucosamine sulfate.
The product has a simple formula and simple goal of strengthening and protecting your joints. One bottle contains a two month supply for one person. Capsules should be taken twice daily to make your joint movements comfortable. Puritan’s Pride helps alleviate joint stress. This product is ideal if you find yourself icing a part of your body due to soreness.
Users report less pain in the knees and shoulder after two weeks of taking glucosamine sulfate by Puritan’s Pride. One user stated they take this product to avoid what would otherwise be sharp and grating pain. Many consumers say the capsule is smaller and easier to swallow than many other brands.
Puritan’s Pride helps strengthen nails that are too soft or bend easily. The product is in capsule form, so you can break it open and dissolve it in water if you prefer. It contains no artificial dyes, flavoring, or preservatives. The gelatin used in the capsules comes from a bovine source.
Consumers have reported relief in their ankles, hips, and knees after taking the product. It’s also been reported that joint soreness and stiffness have disappeared. The product is also good for soreness caused by exercise. This product is a good choice for those involved in heavy workouts that are prone to injury or strain.
This formula has also helped alleviate neck stiffness and enhanced range of motion. Many people take this product to alleviate joint pain caused by arthritis. It takes approximately 4-6 weeks on average to feel the effects of taking Nature Made TripleFlex.
Some consumers are disappointed by the large size of the pills. However, many people report a variety of physical improvements. There are a number of consumers who have used this product for years and continue to re-buy it. This is a great nutritional supplement for someone needing additional support for their joints and cartilage.
Top features:
- Nutritional support for your joints
- Eases stiffness due to aging
- A preventative supplement to maintain healthy cartilage and joints
- Reduces joint pain during movement